Encephalopathy associated with occult neuroblastoma

Abstract

✓ The authors report four cases of occult neuroblastoma in children with the striking clinical findings of opsoclonus, myoclonus, and ataxia. The diagnostic value of plain roentgenograms of the chest and abdomen or an intravenous pyelogram is emphasized. Assays for vanillyl mandelic acid and cystathionine may be of value. The clinical course and pathogenesis of encephalopathies due to neuroblastoma are discussed.