Stereotactic body radiotherapy for spinal metastases: current status, with a focus on its application in the postoperative patient

Author:

Sahgal Arjun12,Bilsky Mark3,Chang Eric L.4,Ma Lijun5,Yamada Yoshiya3,Rhines Laurence D.6,Létourneau Daniel1,Foote Matthew1,Yu Eugene7,Larson David A.6,Fehlings Michael G.8

Affiliation:

1. Department of Radiation Oncology, Princess Margaret Hospital;

2. Sunnybrook Health Sciences Centre;

3. Departments of Radiation Oncology and Neurosurgery, Memorial Sloan–Kettering Cancer Center, New York, New York;

4. Departments of Radiation Oncology and

5. Departments of Radiation Oncology and Neurosurgery, University of California San Francisco, California

6. Neurosurgery, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas; and

7. Department of Radiology and Otolaryngology–Head and Neck Surgery, University Health Network, Mount Sinai Hospital and Women's College Hospital; and

8. Division of Neurosurgery and Spinal Program, Toronto Western Hospital, University of Toronto, Ontario, Canada;

Abstract

Stereotactic body radiotherapy (SBRT) for spinal metastases is an emerging therapeutic option aimed at delivering high biologically effective doses to metastases while sparing the adjacent normal tissues. This technique has emerged following advances in radiation delivery that include sophisticated radiation treatment planning software, body immobilization devices, and capabilities of detecting and correcting patient positional deviations with imageguided radiotherapy. There are limited clinical data specifically supporting the role of SBRT as a superior alternative to conventional radiation in the postoperative patient. The focus of this review was to examine the evidence pertaining to spine SBRT in the treatment of spinal metastases and to provide a comprehensive analysis of published patterns of failure, with emphasis on the postoperative patient.

Publisher

Journal of Neurosurgery Publishing Group (JNSPG)

Subject

General Medicine

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3. American Association of Physicists in Medicine: Report No. 54: Stereotactic Radiosurgery. Report of Task Group 42, Radiation Therapy Committee Woodbury, NY, American Institute of Physics, 1995. 6–8

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