Neurophysiological detection of iatrogenic C-5 nerve deficit during anterior cervical spinal surgery

Abstract

Object The incidence of postoperative C-5 spinal nerve root palsy following decompressive cervical spinal surgery has been reported to be as high as 12% for anterior procedures and 30% for posterior procedures. The present study was conducted to document the prevalence of iatrogenic C-5 nerve root deficit during anterior cervical spinal surgery, as well as to evaluate the sensitivity and specificity of intraoperative transcranial electrical stimulation (TES)–induced motor evoked potentials (MEPs) and spontaneous electromyographic (EMG) activity for identifying evolving C-5 nerve root impairment. Methods The authors conducted a retrospective study of 238 consecutive anterior cervical spinal procedures performed by a single surgeon at Christiana Care Hospital within a 48-month period. Techniques used to monitor spinal nerve root function included TES-induced MEPs and spontaneous EMG activity from deltoid, biceps, triceps, wrist extensor, and hand intrinsic muscles innervated by the C5–T1 spinal nerve roots. Spinal cord function was monitored by recording TES-induced MEPs from upper- and lower-extremity muscles as well as somatosensory evoked potentials from stimulation of the ulnar and posterior tibial nerves. Conclusions Transcranial electrical stimulation–induced MEPs and spontaneous EMG activity offer complementary information about evolving iatrogenic C-5 spinal nerve root impairment during anterior cervical spinal surgery. The TES-induced MEPs provide prognostic information and show increased sensitivity to C-5 deficit compared with spontaneous EMG activity alone. Monitoring of spinal nerve root function using only EMG activity carries a risk of false-negative findings; without timely warning of impending neurological impairment, timely intervention to prevent permanent deficit cannot occur.