Experimental epsilon-aminocaproic acid (EACA) administration in the presence of subarachnoid blood

Abstract

✓ Epsilon-aminocaproic acid (EACA) was administered to dogs intrathecally, orally, or intravenously with blood present in the subarachnoid space. These animals were compared with appropriate controls with regard to the subsequent transport of intrathecally injected radioactive albumin from cerebrospinal fluid (CSF) to the blood and the presence of hydrocephalus or adhesive arachnoiditis at the various times of sacrifice. An adhesive arachnoiditis sufficient to produce hydrocephalus or a delay in CSF protein effluence was not observed. The administration of EACA to dogs in the presence of subarachnoid blood did not appear to be associated with any deleterious effects.