Safety and efficacy of a novel neurosurgical enhanced recovery after surgery protocol for elective craniotomy: a prospective randomized controlled trial
Author:
Wang Yuan1, Liu Bolin1, Zhao Tianzhi1, Zhao Binfang1, Yu Daihua2, Jiang Xue1, Ye Lin3, Zhao Lanfu1, Lv Wenhai1, Zhang Yufu1, Zheng Tao1, Xue Yafei1, Chen Lei1, Sankey Eric4, Chen Long1, Wu Yingxi1, Li Mingjuan1, Ma Lin1, Li Zhengmin2, Li Ruigang1, Li Juan1, Yan Jing3, Wang Shasha3, Zhao Hui2, Sun Xude2, Gao Guodong1, Qu Yan1, He Shiming1
Affiliation:
1. Departments of Neurosurgery, 2. Anesthesiology, and 3. Nutrition, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China; and 4. Department of Neurosurgery, Duke University Hospital, Durham, North Carolina
Abstract
OBJECTIVEAlthough enhanced recovery after surgery (ERAS) programs have gained acceptance in various surgical specialties, no established neurosurgical ERAS protocol for patients undergoing elective craniotomy has been reported in the literature. Here, the authors describe the design, implementation, safety, and efficacy of a novel neurosurgical ERAS protocol for elective craniotomy in a tertiary care medical center located in China.METHODSA multidisciplinary neurosurgical ERAS protocol for elective craniotomy was developed based on the best available evidence. A total of 140 patients undergoing elective craniotomy between October 2016 and May 2017 were enrolled in a randomized clinical trial comparing this novel protocol to conventional neurosurgical perioperative management. The primary endpoint of this study was the postoperative hospital length of stay (LOS). Postoperative morbidity, perioperative complications, postoperative pain scores, postoperative nausea and vomiting, duration of urinary catheterization, time to first solid meal, and patient satisfaction were secondary endpoints.RESULTSThe median postoperative hospital LOS (4 days) was significantly shorter with the incorporation of the ERAS protocol than that with conventional perioperative management (7 days, p < 0.0001). No 30-day readmission or reoperation occurred in either group. More patients in the ERAS group reported mild pain (visual analog scale score 1–3) on postoperative day 1 than those in the control group (79% vs. 33%, OR 7.49, 95% CI 3.51–15.99, p < 0.0001). Similarly, more patients in the ERAS group had a shortened duration of pain (1–2 days; 53% vs. 17%, OR 0.64, 95% CI 0.29–1.37, p = 0.0001). The urinary catheter was removed within 6 hours after surgery in 74% patients in the ERAS group (OR 400.1, 95% CI 23.56–6796, p < 0.0001). The time to first oral liquid intake was a median of 8 hours in the ERAS group compared to 11 hours in the control group (p < 0.0001), and solid food intake occurred at a median of 24 hours in the ERAS group compared to 72 hours in the control group (p < 0.0001).CONCLUSIONSThis multidisciplinary, evidence-based, neurosurgical ERAS protocol for elective craniotomy appears to have significant benefits over conventional perioperative management. Implementation of ERAS is associated with a significant reduction in the postoperative hospital stay and an acceleration in recovery, without increasing complication rates related to elective craniotomy. Further evaluation of this protocol in large multicenter studies is warranted.Clinical trial registration no.: ChiCTR-INR-16009662 (chictr.org.cn)
Publisher
Journal of Neurosurgery Publishing Group (JNSPG)
Subject
Genetics,Animal Science and Zoology
Reference42 articles.
1. Transcranial minimally invasive neurosurgery for tumors;Garrett;Neurosurg Clin N Am,2010 2. Regional scalp block for postcraniotomy analgesia: a systematic review and meta-analysis;Guilfoyle;Anesth Analg,2013 3. Influence of non-ventilatory options on postoperative outcome;Chappell;Best Pract Res Clin Anaesthesiol,2010 4. Enhanced recovery after surgery for oncological craniotomies;Hagan;J Clin Neurosci,2016 5. Computerized tomographic determination of human thigh components. The effects of immobilization in plaster and subsequent physical training;Ingemann-Hansen;Scand J Rehabil Med,1980
Cited by
79 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|