Clinical outcomes following resection of paraspinal ganglioneuromas: a case series of 15 patients

Author:

Goldberg Jacob L.12,Hussain Ibrahim2,Carnevale Joseph A.12,Giantini-Larsen Alexandra12,Barzilai Ori1,Bilsky Mark H.12

Affiliation:

1. Department of Neurosurgery, Memorial Sloan Kettering Cancer Center;

2. Department of Neurosurgery, Weill Cornell Medical College, New York, New York

Abstract

OBJECTIVE Paraspinal ganglioneuromas are rare tumors that arise from neural crest tissue and can cause morbidity via compression of adjacent organs and neurovascular structures. The authors investigated a case series of these tumors treated at their institution to determine clinical outcomes following resection. METHODS A retrospective review of a prospectively collected cohort of consecutive, pathology-confirmed, surgically treated paraspinal ganglioneuromas from 2001 to 2019 was performed at a tertiary cancer center. RESULTS Fifteen cases of paraspinal ganglioneuroma were identified: 47% were female and the median age at the time of surgery was 30 years (range 10–67 years). Resected tumors included 9 thoracic, 1 lumbar, and 5 sacral, with an average maximum tumor dimension of 6.8 cm (range 1–13.5 cm). Two patients had treated neuroblastomas that matured into ganglioneuromas. One patient had a secretory tumor causing systemic symptoms. Surgical approaches were anterior (n = 11), posterior (n = 2), or combined (n = 2). Seven (47%) and 5 (33%) patients underwent gross-total resection (GTR) or subtotal resection with minimal residual tumor, respectively. The complication rate was 20%, with no permanent neurological deficits or deaths. No patient had evidence of tumor recurrence or progression after a median follow-up of 68 months. CONCLUSIONS Surgical approaches and extent of resection for paraspinal ganglioneuromas must be heavily weighed against the advantages of aggressive debulking and decompression given the complication risk of these procedures. GTR can be curative, but even patients without complete tumor removal can show evidence of excellent long-term local control and clinical outcomes.

Publisher

Journal of Neurosurgery Publishing Group (JNSPG)

Subject

General Medicine

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Maturation of metastases in peripheral neuroblastic tumors (neuroblastoma) of children;Journal of Neuropathology & Experimental Neurology;2023-09-20

2. Spinal Ganglioneuroma;World Neurosurgery;2022-06

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