Use of microfibrillar collagen as a topical hemostatic agent in brain tissue

Abstract

✓ Microfibrillar collagen, a recently introduced topical hemostatic agent, was used to obtain hemostasis in suction-evacuation lesions of canine cortex. Gelatin foam was used as a control in identical lesions on the opposite side. Microfibrillar collagen was found to be faster acting and more effective than gelatin foam. Histological evaluation of the lesions at 2, 4, and 6 months postoperatively showed no significant difference in the amount or type of tissue reaction to the two agents.