Induction of a therapeutic antitumor immunological response by intratumoral injection of genetically engineered Semliki Forest virus to produce interleukin-12

Author:

Yamanaka Ryuya,Zullo Susan A.,Tanaka Ryuichi,Ramsey Jay,Blaese Michael,Xanthopoulos Kleanthis G.

Abstract

Object The authors investigated immunogene therapy for malignant glioma to determine whether its therapeutic efficacy could be improved. Methods Four groups of 203-glioma–bearing mice were treated with injections of phosphate-buffered saline, Semliki Forest virus (SFV)–LacZ, retrovirus vector DFG–interleukin (IL)–12, and SFV-IL12, respectively. The results indicated that therapeutic immunization with SFV-IL12 prolonged the survival of mice with established tumors. Semliki Forest virus induces apoptotic death to glioma cells, which facilitates the uptake of apoptotic cells by dendritic cells, providing a potential mechanism for enhanced immunogenicity. Conclusions Immunogene therapy with IL-12 via SFV may be an excellent candidate for the development of new cancer vaccines.

Publisher

Journal of Neurosurgery Publishing Group (JNSPG)

Subject

Clinical Neurology,General Medicine,Surgery

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