Deficiency of gonadotropin-releasing factor in a patient with hydrocephalus internus

Abstract

✓ The authors present the case of a 21-year-old woman with primary amenorrhea and hydrocephalus internus, and suggest that the amenorrhea was probably caused by insufficient basal and cyclic activity of luteinizing hormone/releasing hormone-producing neurons in the hypothalamus. The amenorrhea persisted after ventriculocisternotomy; only after several therapeutic trials with estrogens and progesteron did spontaneous menstrual periods appear more than 5 years after operation.