Author:
Roberts David W.,Coughlin Christopher T.,Wong Terence Z.,Fratkin Jonathan D.,Douple Evan B.,Strohbehn John W.
Abstract
✓ An oncolytic effect of hyperthermia in the 42° to 43°C range has been previously demonstrated in cell culture and animal models. To apply this modality clinically, an interstitial microwave antenna array system has been developed for the delivery of controlled hyperthermia to an intracranial tumor volume, and a Phase I clinical trial involving six patients with malignant gliomas was undertaken. The protocol to study technical feasibility and patient tolerance combined interstitial iridium-192 irradiation and interstitial hyperthermia with 60-minute hyperthermia sessions immediately before and after brachytherapy. After-loading catheters suitable for both treatment modalities were implanted using a computerized tomography-assisted technique. Thermometry data confirmed the ability of a microwave antenna system to achieve reliable temperature distributions, and reasonable patient tolerance was documented.
Publisher
Journal of Neurosurgery Publishing Group (JNSPG)
Cited by
91 articles.
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