Laser scanning confocal endomicroscopy in the neurosurgical operating room: a review and discussion of future applications

Author:

Mooney Michael A.1,Zehri Aqib H.23,Georges Joseph F.2,Nakaji Peter1

Affiliation:

1. 2Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix; and

2. 1Neurosurgery Research Laboratory,

3. 3College of Medicine, The University of Arizona, Phoenix, Arizona

Abstract

Laser scanning confocal endomicroscopy (LSCE) is an emerging technology for examining brain neoplasms in vivo. While great advances have been made in macroscopic fluorescence in recent years, the ability to perform confocal microscopy in vivo expands the potential of fluorescent tumor labeling, can improve intraoperative tissue diagnosis, and provides real-time guidance for tumor resection intraoperatively. In this review, the authors highlight the technical aspects of confocal endomicroscopy and fluorophores relevant to the neurosurgeon, provide a comprehensive summary of LSCE in animal and human neurosurgical studies to date, and discuss the future directions and potential for LSCE in neurosurgery.

Publisher

Journal of Neurosurgery Publishing Group (JNSPG)

Subject

Clinical Neurology,General Medicine,Surgery

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