Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis-Reference-Cited by-同舟云学术

Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis

Published:2017-05 Issue:5 Volume:126 Page:1472-1478
ISSN:0022-3085
Container-title:Journal of Neurosurgery
language:
Short-container-title:

Author:

Rennert Robert C.¹,Hoshide Reid R.¹,Signorelli Jason W.¹,Amaro Deirdre²,Sack Jayson A.¹,Brennan Cameron W.³,Chen Clark C.¹

Affiliation:

1. Departments of Neurosurgery and

2. Pathology, University of California, San Diego, California; and

3. Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York

Abstract

The authors report an unusual case of a widely metastatic glioblastoma. DNA copy number microarray profile of the resected specimen revealed complex rearrangements found throughout chromosome 6, a phenomenon known as chromothripsis. Such chromothripsis pattern was not observed in 50 nonmetastatic glioblastoma specimens analyzed. Analysis of the 1000+ gliomas profiled by The Cancer Genome Atlas (TCGA) data set revealed one case of chromosome 6 chromothripsis resembling the case described here. This TCGA patient died within 6 months of undergoing tumor resection. Implications of these findings are reviewed in the context of the current literature.

Publisher

Journal of Neurosurgery Publishing Group (JNSPG)

Subject

Genetics,Animal Science and Zoology

Link

https://thejns.org/downloadpdf/journals/j-neurosurg/126/5/article-p1472.xml

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