Author:
Rosner Michael J.,Newsome Heber H.,Becker Donald P.
Abstract
✓ Catecholamine release was studied in cats as a function of injury severity in the fluid-percussion model of brain injury. Hyperglycemia was also studied as a function of catecholamine response and injury severity. Epinephrine (E) and norepinephrine (NE) increased as a function of injury. This increase was maximal at about a 3.0-atmosphere (atm) injury level and amounted to a 500-fold increase for E and 100-fold increase for NE. Both catecholamines increased maximally by 10 seconds postinjury. Glucose increased to about 350% of baseline at 500 seconds postinjury and also increased as a function of injury severity. Results suggested that the sympathoadrenal discharge was capable of a graded response which was maximal at about 3.0 atm. Associated with this increase were hypertension, bradyarrhythmias, tachyarrhythmias, and hyperglycemia.
Publisher
Journal of Neurosurgery Publishing Group (JNSPG)
Cited by
186 articles.
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