Chronic Kidney Disease Observational Cohort Study And Assessment Of Baseline Characteristics And Their Relationship With Diabetes Status And Kidney Function

Abstract

Background: Chronic kidney disease (CKD) may result in end-stage renal disease (ESRD), and undesirable outcomes such as death and dialysis. We carried out an observational cohort study to ascertain risk factors for the renal outcomes, all-cause mortality in patients with CKD. In this report, we studied the baseline demographic and laboratory characteristics of the cohort. Methods: A single-center, retrospective, observational cohort study was conducted at the outpatient Nephrology Clinic of Health Sciences University, Kayseri Medical Faculty, from January 1, 2010, to December 31, 2020. Age 18 to 70 years and eGFR 15 to 59 mL/min/1.73 m2 were inclusion criteria. Baseline demographic and laboratory data were documented. Results: One thousand seventy-three patients with CKD were enrolled in the study. Mean (SD) age was 55.87 (8.83) years, and 53.2% were men. %45.9 and %84.4 had diabetes mellitus and hypertension, respectively. The mean body mass index was 26.73 (3.95) kg/m2. Mean eGFR was 34.14 (10.45) mL/min/1.73 m2 using chronic kidney disease epidemiology collaboration. Median (p25-p75) urinary protein-creatinine ratio was 48.80 [22.40, 89.00] mg/mmol. Older patients had a lower eGFR, and the male gender was more common at stage 3 patients. Stage 4 patients had lower hemoglobin and serum calcium levels. Also, low eGFR was associated with high uric acid levels. Conclusion: This study along with future analysis may elucidate the natural history and clinical consequences of CKD. Controllable factors could be understood, and CKD progression and adverse outcomes may be prevented in this way.