High-yield, Enzymatic Synthesis of 14C- or 3H-Labeled 1-O-Valproyl-β-D-glucopyranuronic Acid, the Main Metabolite of Valproic Acid in Human
Author:
Affiliation:
1. Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.
Publisher
Japan Radioisotope Association
Subject
Radiation
Link
https://www.jstage.jst.go.jp/article/radioisotopes1952/48/6/48_6_383/_pdf
Reference7 articles.
1. 1) Rimmer, E. M. and Richens, A.: An update on sodium valproate, Pharmacotherapy, 5, 171-184 (1985)
2. 2) Nagai, K., Shimizu, T., Togo, A., Takeya, M., Yokomizo, Y., Sakata, Y., Matsuishi, T. and Kato, H.: Decrease in serum levels of valproic acid during treatment with a new carbapenem, panipenem/betamipron (Correspondence) , J. Antimicrob. Chemother., 39, 295-296 (1997)
3. 3) Yamamura, N., Imura, K. and Naganuma, H.: Effect of panipenem on the pharmacokinetics of valproic acid in dogs (in Japanese) , Jpn. J. Che-mother., 46, 81-86 (1998)
4. 4) Spahn-Langguth, H. and Benet L. Z.: Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mecha-nism?, Drug Metab. Rev., 24, 5-48 (1992)
5. 5) Bols, M.: Stereoselective synthesis of 1-O-pivaloyl-β-D-glucopyranuronic acid, J. Org. Chem., 56, 5943-5945 (1991)
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