Author:
Xiong Jixian,Zhang Tiantian,Lan Penglin,Zhang Shuhong,Fu Li
Abstract
Gastric cancer (GC) is one of the most common causes of cancer-related death worldwide, and gastric cancer stem cells (GCSCs) are considered as the major factor for resistance to conventional radio- and chemotherapy. Accumulating evidence in recent years implies that GCSCs regulate the drug resistance in GC through multiple mechanisms, including dormancy, drug trafficking, drug metabolism and targeting, apoptosis, DNA damage, epithelial-mesenchymal transition, and tumor microenvironment. In this review, we summarize current advancements regarding the relationship between GCSCs and drug resistance and evaluate the molecular bases of GCSCs in drug resistance.
Funder
National Natural Science Foundation of China
National Key R&D Program of China
Science and Technology Program of Guangdong Province in China
Industry and Information Technology Foundation of Shenzhen
SZU Top Ranking Project
Guangdong Basic and Applied Basic Research Foundation
Medical Scientific Research Foundation of Guangdong Province
Subject
Pharmacology (medical),Cancer Research
Cited by
5 articles.
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