Some synergetic therapy strategies for overcoming hypoxia for photodynamic therapy of cancer

Author:

Chai Tian,Li Ya,Cai Yeyu,Li Yiyang,Kenar Necla,Lim Hyun Soo,Temple Hunter,Chen Xiangyu,Chen Wei

Abstract

As an emerging strategy in antitumor therapy, photodynamic therapy (PDT) has garnered significant attention in recent years for the treatment of various malignant tumors. This is due to its low side effects, superior spatial selectivity, and maximum preservation of normal tissue function. However, the hypoxic nature of tumors, continuous oxygen consumption, and microvascular damage associated with PDT treatment have impeded its development. Therefore, the focus of antitumor therapy has shifted towards enhancing the efficacy of PDT by addressing tumor hypoxia. The objective of this review is to assess and summarize the recent advancements in tumor treatment using synergistic therapy strategies (PDT+X, where X represents photothermal therapy, chemodynamic therapy, chemotherapy, immunotherapy, Photoacoustic therapy, etc .) that overcome hypoxia. Additionally, this review aims to outline the advantages and disadvantages of various collaborative methods for improving tumor hypoxia, while also discussing the challenges that lie ahead for future research.

Publisher

OAE Publishing Inc.

Subject

Oncology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3