Functional medical approach and management for long COVID

Abstract

Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection or post-acute COVID-19 syndrome, refers to a range of symptoms and complications that persist more than 4 weeks after diagnosis. Common symptoms include fatigue, headache, anosmia, ageusia, chronic cough, shortness of breath, impaired concentration and memory, sleep disturbances, depression, anxiety, and hair loss. The incidence of long COVID varies according to the data, but it has been reported in 20% to 60% of acute COVID-19 patients. Despite its high incidence and significant medical and societal burden, there is currently no clear definition or objective diagnostic criteria for long COVID. Its diagnosis and treatment options are also limited due to insufficient evidence. Nevertheless, a functional medicine approach, through aspects such as adrenal fatigue, gut health, inflammation resolution, histamine imbalance, and vitamin D deficiency, can help long COVID patients. Blood tests, urinary organic acid profile, and food intolerance tests can be utilized, and lifestyle modification, oral or intravenous nutrition therapies can be implemented. In this article, we review the existing medical literature on long COVID and propose a functional medicine approach and management for long COVID.