Effects of Mucoadhesive Gel Containing Propolis on Some Biochemical and Hematologic Parameters in Rats With Experimental Periodontitis

Abstract

This study aimed to investigate the effects of propolis-containing mucoadhesive gel in experimentally induced periodontitis in rats. Propolis-containing mucoadhesive gel was prepared by using chitosan with a modified mechanical method. Thirty-five Sprague Dawley rats were used in the study. Rats were divided five groups as negative control, periodontitis + 50 mg/dl propolis, periodontitis + 100 mg/dl propolis, periodontitis + chitosan and healthy control. Experimental periodontitis was induced by placing ligatures on the inferior frontal teeth. After 11 days, the ligatures were removed, and gel applications were started. On the eighth day, blood samples were taken under anaesthesia. Haematological and biochemical analyses were performed from whole blood and serum samples. As a result of the statistical analysis, non-statistically significant decreases were determined in serum CRP, IL-1, IL-6 and TNF-α levels in the groups that were applied a mucoadhesive gel containing propolis. As a result, it was thought that mucoadhesive gel containing propolis might help treat periodontitis.