Evaluation of the Dispensing Rate of Isoniazid Used in the Preventive Treatment of Tuberculosis in a Service Specialized in HIV / AIDS

Abstract

Introduction: Acquired immunodeficiency syndrome caused by the human immunodeficiency virus was one of the main epidemics of infectious diseases of the 20th century. Tuberculosis is a chronic, infectious and contagious disease caused by Mycobacterium tuberculosis. Both diseases interact becoming a major public health problem. Preventive treatment with isoniazid has an option for non-manifestation of tuberculosis. Treatment adhering is essential for successful prevention. Objective: To evaluate the rate of compliance with preventive treatment with isoniazid, measured through the dispensation of the drug in the pharmacy and the factors associated between subjects with HIV/AIDS and Latent infection by Mycobacterium tuberculousis followed in specialized service in the care of HIV/AIDS patients. Methodology: Retrospective and prospective, descriptive and analytical study with adult patients with HIV/AIDS in follow-up, Extension Service for the Care of HIV/AIDS Patients of the Division of Infectious and Parasitic Diseases of the Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo, using the Hospital Information and Management System (SIGH) implemented in the Outpatient Clinics and Pharmacy Service, and performing the analysis of association between the variables of interest and outcome through the student’s t-test with 95% CI, being considered with statistical significance p ≤ 5%. Results: We included 161 subjects who participated in the study being 78.9% male, 67.7% under 50 years of age, 87.0% with more than 5 years of HIV infection, and complications during preventive treatment were present in 12.4% (20). The rate of adhering to preventive treatment with isoniazid in medical records and electronic prescription was 96% and 83%, respectively, both being higher than 80% according to the recommendation of the World Health Organization and there was no association between the variables of interest and outcome. Conclusion: The high rate can be partially justified by practices adopted in medical and pharmaceutical care such as scheduling drug dispensing dates, unification for dispensing of different medications on the same date, information in the pharmacy about factors that increase the effectiveness of treatment. The adequate care and care provided was ultimately the great responsible for the results achieved.