STRUCTURAL AND FUNCTIONAL CHANGES IN BONE TISSUE OF THE SPINE AND EXTREMITIES IN OXYS RATS-Reference-Cited by-同舟云学术

STRUCTURAL AND FUNCTIONAL CHANGES IN BONE TISSUE OF THE SPINE AND EXTREMITIES IN OXYS RATS

Published:2006-04-12 Issue:1 Volume: Page:088-094
ISSN:2313-1497
Container-title:Hirurgiâ pozvonočnika
language:
Short-container-title:Hir. pozvonoč.

Author:

Falameeva Olga Viktorovna¹,Sadovoy Mikhail Anatolyevich¹,Khrapova Yulia Viktorovna¹,Kolosova Natalya Gorislavovna²

Affiliation:

1. Novosibirsk Research Institute of Traumatology and Orthopaedics

2. Institute of Citology and Genetics, SB RAS, Novosibirsk

Abstract

Objective. To study specific structural and functional changes in bone tissue in Oxys rats of different age. Material and Methods. Mineral density of bone tissue in Oxys and Wistar male rats at the age of 2–18 months was examined with x-ray bone densitometer LUNAR-Exert-XL (USA). Bone fragments of vertebral bodies and of forelegs and hind legs were studied by histomorphometric assay with software Motic Images Plus 2.0 ML (Micromed, Russia). Results. X-ray bone densitometry findings have shown that bone mineral density increase in Oxys rats does not attain the values shown by age-matched control rats, and progressively decreases after the age of 6 months. Data obtained by histomorphometric analysis of vertebral bodies and limbs have reliably demonstrated that there is a change in quantitative and qualitative bone tissue parameters of Oxys rats which is a characteristic of osteoporosis. Conclusion. Bone tissue changes in Oxys rats correspond to that observed in human osteoporosis, what allows to use rat as a model for the study of osteoporosis pathogenesis and for development of prophylaxis and treatment methods.

Publisher

Association of Spine Surgeons

Subject

Anesthesiology and Pain Medicine,Orthopedics and Sports Medicine,Surgery

Reference16 articles.

1. Kolosova N.G., Kutorgin G.D., Safina A.F. Osobennosti mineralizatsii kostnoi tkani prezhdevremenno stareyushchikh krys Oxys // Byul. ekspep. biologii. 2002. T. 133. № 2. S. 203–206.

2. Kolosova N.G., Lebedev P.A., Aidagulova S.V. i dr. Krysy Oxys kak model' senil'noi katarakty // Byul. eksper. biologii. 2003. T. 134. № 10. S. 235–240.

3. Markova E.V., Obukhova L.A., Kolosova N.G. Pokazateli aktivnosti kletochnogo zvena immunnogo otveta krys linii Vistar i Oxys i osobennosti ikh povedeniya v teste «otkrytogo polya» // Byul. eksper. biologii. 2003. T. 136. № 10. S. 427–429.

4. Solov'eva N.A., Mopozkova T.S., Salganik R.I. Poluchenie sublinii krys s priznakami nasledstvennoi galaktozemii i issledovanie ikh biokhimicheskikh osobennostei // Genetika. 1975. № 5. S. 63–71.

5. Shabalina I.G., Kolosova N.G., Grishanova A.Yu. i dr. Aktivnost' okislitel'nogo fosforilirovaniya, F0F1-ATF-azy i soderzhanie tsitokhromov mitokhondrii pecheni krys s vrozhdennym povysheniem sposobnosti radikaloobrazovaniya // Biokhimiya. 1995. T. 60. № 12. S. 2045–2052.

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