Affiliation:
1. Novosibirsk Research Institute of Traumatology and Orthopaedics
2. Novosibirsk Branch of the S.N. Fyodorov Eye Microsurgery Complex
Abstract
Objective. To analyze quantitative and qualitative composition of glycosaminoglycans in intervertebral disc tissues in patients with idiopathic scoliosis. Material and Methods. Intervertebral discs and growth plates were obtained from 50 patients at the age of 12 to 14 years undergoing surgical correction for idiopathic scoliosis of Grade III–IV with apex in the thoracic spine. Autopsy material (20 samples) from forensic medical examination was used as a norm. Nucleus pulposus, annulus fibrosus and growth plate were anatomically separated from tissues. Results. It was established that qualitative composition of glycosaminoglycans is changed both in all parts of the intervertebral discs and in growth plate. Abundance of keratan sulfate increased and of chondroitin sulfate decreased. A great deal of nonacetylated hexosamines appeared and abundance of sulfate groups reduced. Conclusion. Revealed changes are related to the disorders in synthesis and processes of chain modification in glycosaminoglycans.
Publisher
Association of Spine Surgeons
Subject
Anesthesiology and Pain Medicine,Orthopedics and Sports Medicine,Surgery
Cited by
1 articles.
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