Vertebrogenesis: what the discoveries of the 21st century added into the classical understanding of the embryogenesis of the spine in general and of the craniovertebral zone in particular. Scientific review-Reference-Cited by-同舟云学术

Vertebrogenesis: what the discoveries of the 21st century added into the classical understanding of the embryogenesis of the spine in general and of the craniovertebral zone in particular. Scientific review

Published:2024-07-03 Issue:2 Volume:21 Page:81-89
ISSN:2313-1497
Container-title:Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika)
language:
Short-container-title:Hir. pozvonoč.

Author:

Krasnov I. M.¹^ORCID,Mushkin M. A.²^ORCID,Mushkin A. Yu.³^ORCID

Affiliation:

1. St. Petersburg State University 7–9 Universitetskaya emb., St. Petersburg, 199034, Russia

2. Pavlov First Saint Petersburg State Medical University 6–8 L’va Tolstogo str., St. Petersburg, 194064, Russia

3. St. Petersburg Research Institute of Phthisiopulmonology; Pavlov First Saint Petersburg State Medical University 2–4 Ligovsky prospekt, St. Petersburg, 191036, Russia; 6–8 L’va Tolstogo str., St. Petersburg, 194064, Russia

Abstract

Classical concepts of embryogenesis of the spine, supplemented by modern data on the role of extracellular matrix factors, specific cell adhesionmolecules, signaling molecules, and Hox and Pax genes are presented. They allow us to get closer to understanding the molecular genetic cascades possibly regulating the development of the axial skeleton. Particular attention is paid to the data on the influence of these factors on the morphogenesis of the craniovertebral zone and its defects, primarily associated with segmentation disorders.

Publisher

Association of Spine Surgeons

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