High Performance Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry at Low Magnetic Field-Reference-Cited by-同舟云学术

High Performance Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry at Low Magnetic Field

Published:2002-04 Issue:2 Volume:8 Page:169-176
ISSN:1469-0667
Container-title:European Journal of Mass Spectrometry
language:en
Short-container-title:Eur J Mass Spectrom (Chichester)

Author:

Gorshkov Michael V.¹,Udseth Harold R.²,Anderson Gordon A.²,Smith Richard D.²

Affiliation:

1. Institute of Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russia 117829

2. Pacific Northwest National Laboratory, PO Box 999, Richland, WA 99352, USA

Abstract

A comprehensive characterization of a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer utilizing a 1 tesla magnet with an electrospray ionization (ESI) source is presented. A resolution of up to 10,000,000 and a ppb-level mass accuracy has been achieved for atomic ions and light molecules produced with electron ionization. It has also been demonstrated that a resolution of up to 1,000,000 can be achieved for signals from biomolecule ions obtained with an ESI source, with the highest molecular weight for which the 13C isotopic pattern was completely resolved being that of ubiquitin (8565 Da). Several features of FT-ICR mass spectrometry at low magnetic field are discussed and approaches to overcome the low-field constraints are presented.

Publisher

SAGE Publications

Subject

Spectroscopy,Atomic and Molecular Physics, and Optics,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1255/ejms.486

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