Electrospray Ionization Tandem Mass Spectrometry of Phosphonate Peptides-Reference-Cited by-同舟云学术

Electrospray Ionization Tandem Mass Spectrometry of Phosphonate Peptides

Published:2010-02-01 Issue:4 Volume:16 Page:503-509
ISSN:1469-0667
Container-title:European Journal of Mass Spectrometry
language:en
Short-container-title:Eur J Mass Spectrom (Chichester)

Author:

Zheng Zhenyu¹,Liu Yan¹,Cai Zhenshi²,Zhang Hanwen¹,Fang Hua³,Fang Meijuan²,Zhao Yufen¹²⁴

Affiliation:

1. Department of Chemistry, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People's Republic of China

2. Department of Pharmaceutical Science, Medical College, Xiamen University, Xiamen 361005, People's Republic of China

3. The Third Institute of Oceanography of the State Oceanic Administration, Xiamen 361005, People's Republic of China

4. The Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology, National Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China

Abstract

Phosphonate peptides were synthesized and investigated by positive ion electrospray ionization mass spectrometry in conjunction with tandem mass spectrometry. It was found that, for the sodiated adduct, there were two rearrangement reactions. In path A, there was C–C covalent bond cleavage with consecutive migration of a hydrogen atom to lose the amino alcohol molecule. In path B, two consecutive covalent cleavages of the C–N and P–O bonds occurred.

Publisher

SAGE Publications

Subject

Spectroscopy,Atomic and Molecular Physics, and Optics,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1255/ejms.1072

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