H2 Unimolecular Elimination in Electrospray Ionization Mass Spectrometry from Erythraline, a Spirocyclic Alkaloid-Reference-Cited by-同舟云学术

H2 Unimolecular Elimination in Electrospray Ionization Mass Spectrometry from Erythraline, a Spirocyclic Alkaloid

Published:2013-10 Issue:5 Volume:19 Page:345-350
ISSN:1469-0667
Container-title:European Journal of Mass Spectrometry
language:en
Short-container-title:Eur J Mass Spectrom (Chichester)

Author:

Silva Denise Brentan¹²³,Guaratini Thais³,Vessecchi Ricardo³,Lopes Norberto Peporine³,Cramer Benedikt¹,Humpf Hans-Ulrich¹,Lopes João Luis Callegari³

Affiliation:

1. Institut für Lebensmittelchemie, Westfälische Wilhelms-Universität Münster, Corrensstrasse 45, 48149 Münster, Germany

2. Lychnoflora Pesquisa & Desenvolvimento em Produtos Naturais LTDA, Rua Ângelo Mestriner 263, 14030-090 Vila Virgínia, Ribeirão Preto-SP, Brazil

3. Núcleo de Pesquisa em Produtos Naturais e Sintéticos (NPPNS), Faculdade de Ciências Farmacêuticas de Ribeirão Preto-Universidade de São Paulo, Avenida do Café S/N, 14040-903 Ribeirão Preto-SP, Brazil

Abstract

Erythrina alkaloids, which contain a spirocyclic structure, are well known due to their important biological activity at the central nervous system. In this study, systematic electrospray ionization tandem mass spectrometry (ESI-MS/MS) and ESI-multistage mass spectrometry (MS n) analysis of erythraline have shown an unexpected H2 neutral elimination reaction. We have investigated the formation of these ions by accurate-mass ESI-MS/MS with different analyzers and the data suggest a possible unimolecular reaction of H2 loss.

Publisher

SAGE Publications

Subject

Spectroscopy,Atomic and Molecular Physics, and Optics,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1255/ejms.1243

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