Affiliation:
1. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Abstract
It has been reported that the parasympathomimetic alkaloid arecoline and the nootropic agent guvacoline have been detected in areca nut ( Areca catechu L.) during extraction using a basic medium. Here, we have studied the detection of arecoline and guvacoline in vivo in saliva of a “betel-quid” chewer using liquid-chromatography ion trap mass spectrometry. In this paper, we provide evidence that guvacoline is absent in the neutral aqueous extract of betel nut, but is present in abundance in the aqueous extract with added lime (pH 11.9). In an in vivo experiment, we demonstrated that guvacoline is present in the salivary extracts in the mouth with lime (pH 9.5) and without lime (pH 5.3).
Subject
Spectroscopy,Atomic and Molecular Physics, and Optics,General Medicine
Reference23 articles.
1. International Agency for Research on Cancer, Betel-Quid and Areca-Nut Chewing and Some Areca-Nut- Derived Nitrosamines. World Health Organisation, Geneva, Switzerland, 334 pp. (2004).
2. Henry T.H., The Plant Alkaloids, '4th Edition. J. and A. Churchill, London, UK, 783 pp. (1949).
3. Über den Guvacin‐methylester (Guvacolin) und sein natürliches Vorkommen
4. High-performance liquid chromatographic determination of the alkaloids in betel nut
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献