Letter: Mass Spectrometric Approach of High pH- and Copper-Induced Glutathione Oxidation-Reference-Cited by-同舟云学术

Letter: Mass Spectrometric Approach of High pH- and Copper-Induced Glutathione Oxidation

Published:2013-02 Issue:1 Volume:19 Page:71-75
ISSN:1469-0667
Container-title:European Journal of Mass Spectrometry
language:en
Short-container-title:Eur J Mass Spectrom (Chichester)

Author:

Drochioiu Gabi¹,Ion Laura¹,Ciobanu Catalina¹,Habasescu Laura¹,Mangalagiu Ionel¹

Affiliation:

1. Faculty of Chemistry, Al. I. Cuza University of Iasi, 11 Carol I, Iasi-700506, Romania

Abstract

The interaction between copper ions and γ-L-glutamyl–L-cysteinyl–glycine [glutathione (GSH)] molecules may lead to the formation of the physiologically occurring Cu(I)–[GSH]2 and Cu(II)–GSSG complexes. Since glutathione depletion in neurons and aberrant copper metabolism have been implicated in several neurodegenerative disorders, we studied here the interaction of GSH with copper ions (Cu2+) by electrospray ionization ion trap mass spectrometry (ESI-IT-MS). Besides, we extended this approach to pH in excess of 10 by adding ethanolamine to the solution being investigated. As a result, the ESI-IT-MS spectra revealed novel aspects regarding the speciation of copper–glutathione complex.

Publisher

SAGE Publications

Subject

Spectroscopy,Atomic and Molecular Physics, and Optics,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1255/ejms.1210

Reference24 articles.

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