Investigation of thiol/disulfide homeostasis changes and their relationship with prognosis in sepsis patients

Abstract

Aim: Sepsis is the most common life-threatening syndrome. Oxidative stress is one of the mechanisms involved in the pathogenesis of sepsis. Thiols are antioxidant buffers. Changes in thiol parameters refer to changes in oxidative balance. In this study, we aimed to investigate thiol homeostasis changes in sepsis patients. Methods: We included 99 patients (53 patients diagnosed with sepsis in the Intensive Care Unit and 46 controls). Sepsis patients were divided into two groups based on their diagnosis, follow-up, and disease severity: sepsis and septic shock. Total thiol and native thiol levels were analyzed in the patients and controls. Disulfide levels were calculated. The thiol parameters were compared between the patient and control groups, sepsis and septic shock, mortality, and survivor groups. Results: In sepsis patients, the disulfide/native thiol and disulfide/total thiol rates were significantly higher (p