Affiliation:
1. National University Health System and National University of Singapore (Singapore)
2. Imperial College Healthcare NHS Trust, United Kingdom
Abstract
Sepsis is life-threatening and might potentially progress from dysregulation to
severe organ dysfunction. It is recognised by the World Health Organisation as a
global health priority. The mortality rate for sepsis has decreased in many countries,
and this is credited to the earlier recognition and treatment of this complex syndrome.
In 2002, the Surviving Sepsis Campaign was launched, and there have been several
revisions to the sepsis recommendations therefrom. The latest sepsis guidelines
focus on viral as well as bacterial infections, and advise that initiating resuscitation
and management should take place within one hour from when sepsis is initially
suspected. Numerous studies and guidelines pertaining to sepsis management have
been published over the past 2 decades. The use of novel therapies and alternative
adjunctive therapies has tremendous potential in sepsis management. Debates
amongst intensivists exist with the creation of updated sepsis guidelines and
advances in treatment. The present review article provides both a summary and
recommendations based on the latest clinical evidence and controversies around
sepsis management.
Key words: Critical Care Medicine, Intensive Care Medicine, Respiratory Medicine,
Sepsis, Sepsis Bundles, Sepsis Management
Publisher
Academy of Medicine, Singapore
Reference59 articles.
1. Rubulotta FM, Ramsay G, Parker MM, Dellinger RP, Levy MM, Poeze M. An international survey: public awareness and perception of sepsis. Crit Care Med. 2009 Jan;37(1):167–70.
2. Phua J, Lim HF, Tay CK, Aung NW. Public awareness of sepsis and stroke in Singapore: a population-based survey. Ann Acad Med Singap. 2013 Jun;42(6):269–77.
3. Levy MM, Pronovost PJ, Dellinger RP, et al. Sepsis change bundles: converting guidelines into meaningful change in behavior and clinical outcome. Crit Care Med. 2004 Nov;32(11):S595–7.
4. Dellinger RP, Carlet JM, Masur H, et al. Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004 Mar;32(3):858–73.
5. Dellinger RP, Levy MM, Carlet JM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008 Jan;36(1):296–327.
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献