When Less is More: Can We Abandon Prophylactic Platelet Transfusion in Dengue Fever?-Reference-Cited by-同舟云学术

When Less is More: Can We Abandon Prophylactic Platelet Transfusion in Dengue Fever?

Published:2011-12-15 Issue:12 Volume:40 Page:539-545
ISSN:0304-4602
Container-title:Annals of the Academy of Medicine, Singapore
language:en
Short-container-title:Ann Acad Med Singap

Author:

Kurukularatne Changa¹,Dimatatac Frederico¹,Teo Diana LT²,Lye David C¹,Leo Yee Sin¹

Affiliation:

1. Tan Tock Seng Hospital, Singapore

2. Blood Services Group, Health Sciences Authority, Singapore

Abstract

Dengue fever (DF) has several hematological manifestations including thrombocytopenia and increased bleeding risk. Prophylactic platelet transfusion—in the absence of major bleeding—is utilized in DF with thrombocytopenia with the intention of preventing hemorrhagic complications. However, prophylactic platelet transfusion in DF is neither standardized nor supported by clinical evidence. We conclude that risks, costs and poor resource utilization associated with prophylactic platelet transfusion in DF far outweigh any potential hematological benefit, and as such, should not constitute routine clinical practice. Key words: Thrombocytopenia, Preventitive, Arbovirus, Bleeding, Hemorrhage

Publisher

Academy of Medicine, Singapore

Subject

General Medicine

Reference36 articles.

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