Investigating Sexual Dysfunction in Patients on Isotretinoin, and Evaluating Patient Education Practices among Dermatologists: Survey Study (Preprint)

Abstract

Isotretinoin, a common treatment for severe cystic nodular acne, provides anti-inflammatory effects and alleviates symptoms. Despite its efficacy, the medication has been linked to many well-documented side effects, including arthralgias, xerosis, and birth defects; however, it also introduces new contributions to sexual dysfunction, presenting opportunity for further research and patient education.

To elucidate the prevalence of sexual dysfunction symptoms among patients taking isotretinoin and examine the extent to which these patients received counseling on potential sexual dysfunction from their dermatologist.

Research was conducted through patient completion of a survey study assessing patients’ adverse reactions to isotretinoin and the education provided by their dermatologist.

144 participants completed the survey. Of the female respondents (N=118), 33% experienced vaginal dryness with isotretinoin use, and of the male respondents (N=23), 34.7% experienced erectile dysfunction while using isotretinoin. 6.8% of female participants reported discussing vaginal dryness as a potential side effect with their prescribing dermatologist prior to starting isotretinoin while 4.3% of male respondents reported discussing erectile dysfunction, ejaculatory failure, and delayed ejaculation.

This study demonstrates the opportunity for improved awareness and counseling on isotretinoin’s impact on sexual health.