An ontology to bridge the clinical management of patients and public health responses: a framework for strengthening infectious disease surveillance (Preprint)

Abstract

Novel surveillance approaches using digital technologies, including the Internet of Things (IoT), have evolved, enhancing traditional infectious disease surveillance systems by enabling real-time detection of outbreaks and reaching a wider population. However, disparate, heterogenous infectious disease surveillance systems often operate in silos due to a lack of interoperability. As a life-changing clinical use case, the COVID-19 pandemic has manifested that a lack of interoperability can severely inhibit public health responses to emerging infectious diseases. Interoperability is thus critical for building a robust ecosystem of infectious disease surveillance and enhancing preparedness for future outbreaks. The primary enabler for semantic interoperability is ontology.

This paper aims to design the IoT-based management of infectious disease ontology (IoT-MIDO) to enhance data sharing and integration of data collected from IoT-driven patient health monitoring, clinical management of individual patients, and disparate heterogeneous infectious disease surveillance.

The (IoT-MIDO) was developed using the Basic Formal Ontology (BFO) as the top-level ontology. We reused the classes from existing BFO-based ontologies as much as possible to maximize the interoperability with other BFO-based ontologies and databases that rely on them. We formulated the competency questions as requirements for the ontology to achieve the intended goals.

We demonstrate five use cases using the simplified ontological models to show the potential applications of IoT-MIDO: 1) IoT-driven patient monitoring, risk assessment, early warning, and risk management; 2) clinical patient management of infectious diseases; 3) epidemic risk analysis for timely response at the public health level; 4) infectious disease surveillance; and 5) transforming patient information into surveillance information.

The development of the IoT-MIDO was driven by competency questions. Being able to answer all of the formulated competency questions, we successfully demonstrated that our ontology has the potential to facilitate data sharing and integration for orchestrating IoT-driven patient health monitoring in the context of an infectious disease epidemic, clinical patient management, infectious disease surveillance, and epidemic risk analysis. The novelty and uniqueness of the ontological model lie in building a bridge to link IoT-based individual patient monitoring and early warning based on patient risk assessment to infectious disease epidemic surveillance at the public health level. The ontology can also serve as a starting point to enable potential decision support systems to support public health organisations and practitioners.