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The administration of treatments according to circadian rhythms (chronotherapy) aims at advancing precision medicine through tailoring health care and drug delivery to the patients’ biological clocks. The objective of this paper is to present the IoT platform ‘Clinikali’. ‘Clinikali’ is the first-of-its kind IoT mobile platform of artificial intelligence-assisted home care that we develop, conceptualized as domomedicine. Multidimensional telemonitoring of rest-activity and body temperature circadian rhythms, sleep, and physical activity, jointly with subjective symptoms and quality of life is implemented through wireless BLE sensors and electronic tablets connected via GPRS to the ‘Clinikali’ platform server. Parameters are automatically computed in real time. Alerts are generated whenever threshold values are bypassed. A graphical user interface allows for data and parameters dynamics to be seen by health professionals. Feasibility, compliance and reliability are validated in a field test. The domomedicine platform is currently implemented in the MultiDom trial (NCT04263948), for improving outcomes in frail pancreatic cancer patients receiving chemotherapy. Gathering real time information on individual patients’ circadian rhythms and symptoms generates sensitive early warning signals in order to enhance safety through triggering proactive interventions. Quantitative measures of circadian biomarkers further provide cues for the personalization of chronotherapy. Such domomedicine platform should also help improving outcomes in patients with chronic or infectious diseases, which account for most human mortality.