Application of Computed Tomography Angiography Data Monitoring in Cerebral Glioma (Preprint)

Abstract

Background: Glioma are tumors derived from neuroectodermal stromal cells and one of the most common malignant tumors of the brain.

Objective：The objective is to understand the application of CT angiography in the proliferation of glioma cells more clearly and get more effective diagnosis and treatment of glioma.

Methods： The adult male healthy Sprague Dawley (SD) rats were selected as the research objects to construct the animal models. In addition, respective on the 7th day, 14th day, and the 21st day, the rats were submitted to CT scans. According to parameters and indicators such as cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and time to peak (TTP), the stained cerebral tissues of rats at different time nodes were further analyzed.

Results: The results of rat CT manifestation analysis and clinical analysis showed that with the time increased, the volume of the tumors in rats increased apparently, with symptoms such as listlessness appeared at the initial stage and hemiplegia appeared at the later stage. The comparative analysis results of CT parameters at different times nodes showed that in the same tumor area, before the 14th day, CBF, CBV, and TTP showed the increasing trends, which gradually decreased after the 14th day, with significant statistical difference (P<0.01). However, MTT showed a decreasing trend in general, which is not apparent. The results of Vascular endothelial growth factor (VEGF) staining of the tumor area, the peritumoral area, and the contralateral mirror area at different time nodes showed that the vascular endothelial cells, the smooth muscle cells of vessel walls, and the tumor cells were strongly positive. In addition, with the time increased, in the tumor area, the peripheral area, and the contralateral mirror area, the cells increased in both volume and quantity, showing significant differences.

Conclusion: Therefore, through the research in this study, it is found that the computed tomography angiography data monitoring can reflect the angiogenesis of rat cerebral glioma.