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Hospitals can be overburdened with patients suffering from severe infectious conditions during infectious disease outbreaks. Such outbreaks or epidemics put tremendous pressure on the admission capacity of care facilities in the concerned region, and negatively impact the elective program within these facilities. Such situations have been observed during the recent waves of severe acute respiratory syndrome coronavirus 2 pandemic. Due to the imminent threat of a twindemic by new variant of coronavirus disease 19 and influenza during the upcoming winter season, healthcare agencies should take decisive steps to safeguard hospitals’ surge capacity while continuing to provide optimal and safe care to potentially large number of patients in their familiar home environment. Preparedness of health systems for infectious diseases would require a dynamic interaction between the continuous assessment of region-wide available hospital capacity and programs of intensive home treatment of infectious patients. In this viewpoint we describe an innovative dynamic coupling system between hospital surge capacity and a cascading activation of a nation-wide system for remote patient monitoring.