Determinants of quality of life in interstitial lug disease - preliminary prospective study results from a single center (Preprint)

Abstract

quality of life (QOL) is an important aspect of every chronic disease, including interstitial lung disease (ILD). Data regarding quality of life and its various aspects in ILD other than idiopathic pulmonary fibrosis (IPF), is scarce.

to identify determinants of quality of life57 participants were recruited, including 22 with idiopathic interstitial pneumonias (IIPs), 19 with connective tissue associated ILD (CTD-ILDs) and 16 with interstitial pneumonia with autoimmune features (IPAF). To assess QOL Saint George Respiratory Questionnaire (SGRQ) and World Health Organization QOL questionnaire abbreviated version (WHOQOL-BREF) and depression questionnaires; (Hospital Anxiety and Depression Scale — Modified Version; HADS-M, Patient Health Questionnaire 9; PHQ-9) were analyzed. Functional parameters including forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), transfer lung capacity for carbon monoxide (TLCO) and activity capacity expressed as 6 minute walk test distance (6MWD)were assessed. in patients with ILD

57 participants were recruited, including 22 with idiopathic interstitial pneumonias (IIPs), 19 with connective tissue associated ILD (CTD-ILDs) and 16 with interstitial pneumonia with autoimmune features (IPAF). To assess QOL Saint George Respiratory Questionnaire (SGRQ) and World Health Organization QOL questionnaire abbreviated version (WHOQOL-BREF) and depression questionnaires; (Hospital Anxiety and Depression Scale — Modified Version; HADS-M, Patient Health Questionnaire 9; PHQ-9) were analyzed. Functional parameters including forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), transfer lung capacity for carbon monoxide (TLCO) and activity capacity expressed as 6 minute walk test distance (6MWD)were assessed.

a moderate positive correlation was found in each group between FEV1 pred. v. and a weak positive correlation between TLCO pred.v. and WHOqolBREF physical domain score (p= 0.001 and p= 0.031, respectively). Regardless of diagnosis, higher depression, anxiety and aggression scores correlated negatively with multiple domains of QOL measured by WHOqolBREF. Predictors of QOL aspects varied in each group. In IPAF group, a predictor of QOL expressed as SGRQ total score was TLCO % pred. v. (p=0.005). In CTD-ILD group, short 6MWT and high HADS-M aggression score were correlated with low QOL (high total SGRQ) – p=<0.001 and p=0,.012, respectively. In IIP group, two predictors for SGRQ symptoms scores were revealed: 6MWD (p=0.002) and PHQ-9 score (p= <0.001).

QOL is a multifaceted issue. 6MWT distance, TLCO pred. v. and worse functional ability might specifically impact QoL in ILD.

ClinicalTrials.gov Identifier: NCT03870828