UNSTRUCTURED
Since COVID-19 vaccines became broadly available to the adult population, sharp divergences in uptake have emerged along partisan lines. Researchers have pointed to a polarized social media presence contributing to the spread of mis-/dis-information as being responsible for these growing partisan gaps in uptake. The major aim of this study was to identify and describe influential actors, topics, behaviors, and community structures related to COVID-19 vaccine conversations on Twitter prior to the vaccine roll-out to the general population and discuss implications for vaccine promotion and policy. Using Twitter data on COVID-19 vaccination during July 2020, we found that Twitter vaccine conversations were highly polarized with different actors occupying separate “clusters.” The anti-vaccine cluster was the most densely connected group. Among the 100 most influential actors, medical experts are outnumbered both by partisan actors and by activist vaccine skeptics/conspiracy theorists. Scientists and medical actors were largely absent from the conservative network, and anti-vaccine sentiment was especially salient among actors on the political right. Conversations related to COVID-19 vaccines are highly polarized along partisan lines with “trust” in vaccines being manipulated to the political advantage of partisan actors.