Effectiveness of a mHealth intervention with short text messages to promote treatment adherence among Mexican adults patients with HIV: A randomized clinical trial (Preprint)

Author:

Del Moral Trinidad Luis EduardoORCID,Andrade-Villanueva Jaime FedericoORCID,Martínez Ayala PedroORCID,Cabrera Silva Rodolfo IsmaelORCID,Herrera Godina Melva GuadalupeORCID,Gonzalez-Hernandez LuzORCID

Abstract

BACKGROUND

n 2022, 39 million people lived with HIV, and efforts target the 95-95-95 goal by 2030. In Mexico, key affected populations include men who have sex with men, drug users, sex workers, and transgender individuals. Adherence to treatment is vital, influenced by patient-provider relationships and access to care. eHealth interventions, notably SMS reminders, show promise in enhancing adherence.

OBJECTIVE

To evaluate the effectiveness of a mHealth intervention on ART adherence amongst adult PLWHIV

METHODS

A randomized clinical trial on adult patients who attended the tertiary care from the university hospital “Hospital Civil de Guadalajara – Fray Antonio Alcalde” to initiate ART. mHealth intervention included the use of short message service (SMS) to interact with the patient and as a reminder system for upcoming medical examinations or ART resupply during a 6-month period. A control group (n=40) received medical attention by the standard protocol used in the hospital. Intervention effectiveness was assessed by quantifying CD4+ T cells, viral load, and a self-report of adherence by the patient.

RESULTS

The intervention group had greater adherence to ART than control (96% vs 92%, p = < .0001). In addition, the intervention group had better clinical characteristics, including lower viral load (141 cop/mL vs 2413 cop/mL, p = <.0001) and a tendency for a major number of CD4+ T cells (399 vs 290 cells/uL).

CONCLUSIONS

These results show that mHealth intervention significantly improves ART adherence. Implementing mHealth programs can improve the commitment of PLWHIV to their treatment.

CLINICALTRIAL

NCT05187741

Publisher

JMIR Publications Inc.

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