Opioid therapy for pain in individuals with metastatic cancer: benefits, harms, and stakeholder perspectives: A Protocol Paper (Preprint)

Abstract

Opioids are a key component of pain management among patients with metastatic cancer pain. However, the evidence base available to guide opioid-related decision-making in individuals with advanced cancer is limited.

This manuscript outlines the protocol the “Opioid therapy for pain in individuals with metastatic cancer: The BEnefits, harms, and STakeholder perspectives (BEST) study”.

This is a multicenter, prospective cohort study that aims to enroll 630 patients with advanced cancer, 20 care partners, and 20 clinicians (670 total participants).

The data collection is underway at four clinical sites and results will be reported in future manuscripts.

Upon successful execution of our study protocol, we anticipate the development of a comprehensive evidence-base on opioid therapy in individuals with advanced cancer guided by the Behavioral Decision Research framework.

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