“Quantifying Benefit-Risk Trade-Offs Toward Prophylactic Treatment Among Adult Patients with Hemophilia A in China: Discrete Choice Experiment Study”: comments from Huang et al. (Preprint)

Abstract

With great interest, we read about the paper by Wang et al. which described a discrete choice experiment among adult patients with hemophilia A in China. The results are not surprising and in accordance with clinical routine.[1] It provides valuable insights into the preferences of patients as for prophylaxis in hemophilia A. In this research, the annual bleeding rate was assigned as an important item in the questionnaire. This is rational as most clinical studies (in hemophilia) take it as main clinical outcome. However, the annual bleeding rate should be more specific for the at least joint bleeding and spontaneous bleeding.