BACKGROUND
Psoriasis, a persistent and widespread inflammatory skin condition affecting around 3% of the global population, goes beyond surface-level manifestations, leading to systemic challenges. This ailment is closely linked to an increased susceptibility to a range of systemic conditions, notably cardiovascular diseases, metabolic syndrome, obesity, and psychological disorders. Integrating systemic biomarkers like the triglyceride glycemic index (TyG) index and utilizing non-invasive techniques such as carotid artery intima-media thickness (CIMT) measurement through sonography are valuable approaches to comprehensively assess cardiovascular risk and manage systemic complications in individuals with psoriasis.
OBJECTIVE
The study aims to investigate triglyceride glycaemic index and cardiac Doppler findings in psoriasis patients, establishing correlations between triglyceride glycaemic index and Carotid Doppler study results.
METHODS
60 participants who meet the inclusion criteria will be chosen and divided into two groups, each consisting of 30 individuals. Group A will comprise patients diagnosed with psoriasis. At the same time, Group B will consist of healthy controls with non-inflammatory dermatological conditions other than psoriasis matched in terms of age, sex, and BMI range to the cases. Triglyceride levels, glycemic index, and carotid Doppler scans will be conducted for both groups.
RESULTS
Results will be drawn from the observations of subjective and objective parameters
CONCLUSIONS
The study provides a quantitative key indicator for establishing a relationship between the triglyceride glycemic index and carotid Doppler study findings for atherosclerosis in psoriasis patients
CLINICALTRIAL
Clinical Trials Registry - India (ICMR-NIMS)
REF/2024/03/081271