UNSTRUCTURED
Background:
Sarcomas are rare cancer with heterogeneous group of tumours. Metastasis is often fatal, and current prognostic methods are limited. Recent findings show that sarcoma cells release small extracellular vesicles. Studying them can help assess cancer development, progression, and treatment effectiveness. This study aims to demonstrate the potential of small extracellular vesicles for monitoring the disease and predicting recurrence risk.
Methods: A multicentric, prospective pilot study that will include 30 adults’ patients with localized or metastatic sarcoma. Small extracellular vesicles will be isolated from blood samples and protein and miRNA concentration will be determined. Research will last, on average, 6 months for patients with localized sarcoma and 4 months for patients with metastatic sarcoma. The study is sponsored by the Georges-François Leclerc Center and is currently ongoing.
Discussion: Our innovative approach could improve sarcoma patient management through a non-invasive technique to predict treatment response and/or disease progression.
Trial Registration: ClinicalTrials.gov identifier NCT03800121. Registered January 11, 2019, https://clinicaltrials.gov/ct2/show/study/NCT03800121
Keywords: Pilot-study, liquid biopsy, exosomes, sarcoma, cancer monitoring.