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Remote patient monitoring (RPM) enables clinicians to maintain and adjust their patients’ plan of care by utilizing remotely gathered data, such as vital signs, to proactively make medical decisions about a patient’s care. RPM interventions have been touted as a means to improve patient care and well-being while reducing the costs and resource needs within the healthcare ecosystem. However, multiple interworking components must be successfully implemented for an RPM intervention to yield the desired outcomes, and the design and key driver of each component can vary depending on the medical context. This viewpoints and perspectives paper presents a four-component RPM infrastructure framework based on a synthesis of existing literature and practice related to RPM. Within each of the four components, questions affecting research and practice emerge that can affect the outcomes of RPM interventions. This framework provides a holistic perspective of the technologies involved in RPM interventions and how those core elements interact to provide an appropriate infrastructure for deploying RPM in health systems.