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Background: This Health Information Systems’ (HIS) integration project reports a successful implementation experience of HIS integration with the pharmaceutical Pyxis system, that is used for medication dispensing. The Information Technology (IT) department in King Khalid Eye Specialist Hospital (KKESH) in Kingdom of Saudi Arabia led this project to its final successful deployment. Rhapsody Engine successful adoption in the integration process helped KKESH achieve their productivity goals by enhancing hospital’s staff daily duties and clinical workflow. It also eliminated the system’s errors and alerting notifications. Objective: This experience paper discusses three main questions: What is the power of systems integration? What are the systems’ integration standards? What are the main key performance indicators for ITD related projects? It also discusses the implemented solutions that solved many potential problems that could be encountered by similar big organizations such as the KKESH. Method: The adopted solution was implementing the Rhapsody integration engine to integrate HIS with Pyxis machines. Results: The hospital reported successful piloting implementation of this project. Some key lessons learned from this project experience are demonstrated and documented at the end of the paper.