BACKGROUND
Animal Ethics Committees (AECs) are concerning possibilities for public participation in the regulation of animal research. AECs are accountable for approving and monitoring research within Accredited Animal Research Establishments (AARE) (https://www.animalethics.org.au/animal-ethics-committees). In the way of making mouse models of cancer, several new considerations should be mentioned before the study design.
OBJECTIVE
To consider both personnel and animal welfare decisions at each stage of making mouse models of cancer, it is essential to have comprehensive information on the animal models.
METHODS
Three main cancer models are including; chemically induced mouse models, genetically engineered mouse models (GEMMs), xenograft nude mice, and Avatar. Some genetic changes in GEMMs are passing through next generations and not only do they have pain and suffering but also, they impose some environmental changes on mice.
RESULTS
Several phenotypes are required regarding the target of tumor model that expressed research are typically wisely investigated, but those that have an influence on the animal's welfare but have little or no effect on the disease procedure are often less carefully considered.
CONCLUSIONS
Complete analysis and regulations of animal welfare can offer beneficial information for researchers. This information is similarly essential to allow members of the institutional animal care and use committee to make necessary cost: benefit ethical review of animal studies.
CLINICALTRIAL
Not Applicable