BACKGROUND
NSAIDs inhibit COX-2, which is responsible for regulating neurons leading to neurodegeneration in AD. AD is a neurodegenerative disease affecting the geriatric population, as it affects more than two third cases of dementia in the sphere. Results obtained from experimental and observational studies were unclear regarding the protective role of NSAIDs in AD, therefore this justifies the need for Meta-analysis.
OBJECTIVE
1) Role of NSAIDs, as a protective factor for AD in Experimental study design
2) Role of NSAIDs, as a protective factor for AD in Cohort study design
3) Role of NSAIDs, as a protective factor for AD in Case-Control study design
METHODS
Database search was PubMed, WebScience, and Embase. Experimental studies and Observational studies investigating the effect of NSAIDs on AD. For experimental studies indicators used were MMSE score, ADAS-cog score, CDR-sob score, NPI score, and Hazard ratio. Similarly for Observational studies, Odds Ratio and Relative Risk are used.
RESULTS
The study is ongoing, therefore the result of study still need to be obtained.
CONCLUSIONS
As the result is not obtained, we can not concluded this study.
CLINICALTRIAL
PROSPERO [CRD42022301179]