Effects of visual-motor combined response ability training on cognitive function and brain plasticity mechanism in different populations: a study protocol for a single-center, open-label, controlled clinical trial (Preprint)

Author:

Yu Wenlong,Gao Jiamin,Ma Junming,Zhu PingORCID

Abstract

UNSTRUCTURED

Background: Cognitive impairment is one of the major diseases facing the aging society. the progressive decline of cognitive function will lead to the decline or even loss of life, work and social ability. Exercise and behavioral stimulation can increase neurotransmitters in the brain and improve overall health and cognitive function. Response ability training can mobilize neuromuscular function and induce brain plasticity changes, which may be effective in improving cognitive impairment and delaying the occurrence and progression of Alzheimer’s disease, but the evidence of its effectiveness is still limited. Methods/design: This study is a single-center, open-label, controlled clinical trial. A total of 78 athletes, ordinary healthy college students and ordinary elderly in the community will be recruited. The subjects will receive visual-motor response training for 2 weeks. The primary endpoint of this study was to assess the imaging difference of functional magnetic resonance imaging (fMRI) at 2 weeks. The secondary endpoints are acousto-optic response time, Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), Mini-mental State Examination (MMSE), Activity of Daily Living Scale (ADL), Subjective Cognitive Decline Questionnaire-9 (SCD-Q9), 10-word memory test and safety. Discussion: The purpose of this study is to compare the improvement of brain perceptual motor functional characteristics and cognitive level of different groups of people by response ability training, and to explore the efficacy and safety of exercise-based non-drug therapy in improving cognitive function. Other potential benefits include understanding the functional advantages and perceptual characteristics of the brain’s perceptual motor system between athletes and ordinary people, and exploring the adaptability of the brain to acquire skills in competitive sports training. to provide evidence for the training of early sports talents and a wider range of youth development. Trial registration: Chinese Clinical Trial Registry ID: ChiCTR2400079602. Registered 8 Jan 2024, Available at: www.chictr.org.cn/showproj.html?proj=215669 Abbreviations: AD=Alzheimer’s disease (AD), DMC=data Monitoring Committee, fMRI=functional magnetic resonance imaging

Publisher

JMIR Publications Inc.

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