Genetic factors and anterior cruciate ligament injury risk in professional football players: COL3A1 (rs1800255) and COL5A1 (rs12722) polymorphisms
Author:
İPEKOĞLU Gökhan1ORCID, ÇAKIR Halil İbrahim2ORCID, BOZKURT Nihan3ORCID, BÜLBÜL Alpay4ORCID, SAVKİN Sadegul Tuncer3ORCID, APAYDIN Necdet1ORCID
Affiliation:
1. ORDU UNIVERSITY 2. RECEP TAYYIP ERDOGAN UNIVERSITY 3. TOKAT GAZIOSMANPASA UNIVERSITY 4. ADNAN MENDERES UNIVERSITY
Abstract
This study was conducted to investigate the genotype and allele distributions of COL3A1 (rs1800255) and COL5A1 (rs12722) polymorphisms of professional footballers who have suffered at least 2 anterior cruciate ligament (ACL) injuries non-contact and professional footballers who have never had a ligament injury. The research group consists of 108 professional men's football players ACL group (n=45), Control group (n=63) with at least 10 years of football background. The results ACL and control groups were compared by Chi-square or Fischer’s exact test. There were no significant differences noted neither in terms of genotype distribution of COL3A1 (rs1800255) nor A-allele frequency distribution between control (CON) and ACL group. A highly significant difference in the allele distribution was noted for COL5A1 (rs12722) with the T-allele significantly less frequent in CON than ACL. The TT genotype compared to the C alleles (TC + CC) showed significant relationship between the TT genotype and ACL injury potential in the dominant model. However, it was not showing significance in the recessive (TT + TC vs. CC). In conclusion, it can be said that professional football players who have the COL5A1 rs12722 C allele have about 2 times lower risk of anterior cruciate ligament injury. In the COL3A1 rs1800255 polymorphism, there is no relationship between the groups in terms of genotypes and allele distribution.
Publisher
Turkish Journal of Kinesiology
Reference30 articles.
1. Agel, J., Evans, T. A., & Dick, R. (2007). Descriptive epidemiology of collegiate men’s soccer injuries: National Collegiate Athletic Association Injury Surveillance System, 1988–1989 through 2002–2003. J Athl Train, 42(2), 270–277. 2. Alvarez-Romero, J., Laguette, M. J. N., Seale, K., Jacques, M., Voisin, S., Hiam, D., ... Eynon, N. (2021). Genetic variants within the COL5A1 gene are associated with ligament injuries in physically active populations from Australia, South Africa, and Japan. Eur J Sport Sci, 30, 1-10. 3. Bangsbo, J. (1994). Energy demands in competitive soccer. J Sports Sci, 12, 5–12. 4. Banos, C. C., Thomas, A. H., & Kuo, C. K. (2008). Collagen fibrillogenesis in tendon development: current models and regulation of fibril assembly. Birth defects research. Part C, Embryo Today: Reviews, 84(3), 228-244. 5. Birk, D. E., Fitch, J. M., Babiarz, J. P., Doane, K. J., & Linsenmayer, T. F. (1990). Collagen fibrillogenesis in vitro: interaction of types I and V collagen regulates fibril diameter. J Cell Sci, 95, 649–657.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|