EVALUATION OF ANTIDIABETIC ACTIVITY OF LEUCOMERIS SPECTABILIS EXTRACT IN ALLOXAN-INDUCED DIABETIC RATS

Abstract

The objective of the study is to investigate the hydro alcoholic leaves extract of Leucomeris spectabilis (Asteraceae) for hypoglycemic effects in normal and diabetic rats. Acute oral toxicity study indicated that HAE was safe up to a dose of 2000 mg/kg body weight of rats and screened for antidiabetic activity in alloxan (120 mg/ kg, i.p.) induced diabetic rats for 21 days along with phytochemical analyses of HAE were also carried out. In-vivo evaluation of the extracts decreased blood sugar levels with significant improvement in blood glucose level, serum marker enzymes (SGPT, SGOT and ALP) and the content at the end of 1, 2 and 3rd weeks after HAELC treatment. The results suggest of antidiabetic activity study revealed that HAE possesses significant (p < 0.05) hypoglycemic activity compared to diabetic rats group. The results showed that the hydroalcoholic leaves extract has significantly most of effect in 200mg/kg.  Keywords: Leucomeris spectabilis, Leaves, Acute oral toxicity, Alloxan, Ant-diabetic activity.